Description

Thiol-Peg3-Phosphonic Acid is a specialized heterobifunctional linker molecule that combines a thiol (-SH) group, a triethylene glycol (PEG3) spacer, and a phosphonic acid moiety. This unique structure is critical for creating stable, oriented surface modifications and bioconjugates, particularly in materials science and nanotechnology. It is essential for researchers and manufacturers in pharmaceuticals, diagnostics, and advanced material coatings who require precise surface functionalization and robust anchoring to metal oxides.

Application

• Surface Functionalization of Metal Oxides: The phosphonic acid group provides strong, stable binding to surfaces like titanium dioxide (TiO2), indium tin oxide (ITO), and silica, used in biosensors and medical implants.
• Bioconjugation and Protein/Peptide Modification: The thiol group enables site-specific conjugation to cysteine residues or maleimide-activated biomolecules, facilitating the creation of stable protein-drug conjugates or labeled antibodies.
• Nanoparticle and Quantum Dot Capping: Used to functionalize the surface of nanoparticles and quantum dots, improving solubility in aqueous media and providing a handle for further bio-functionalization via the thiol terminus.
• Development of Self-Assembled Monolayers (SAMs): Acts as a key component for creating ordered molecular layers on metal oxide substrates for corrosion inhibition, electronic devices, and controlled wetting surfaces.
• Linker for Solid-Phase Synthesis and Affinity Chromatography: The phosphonic acid can be immobilized on metal oxide-based resins, with the PEG spacer reducing non-specific binding and the thiol used for capturing or eluting target molecules.
• Crosslinking Agent for Hydrogels and Polymers: Serves as a crosslinker to introduce phosphonate groups into polymer networks, enhancing biocompatibility and metal-chelation properties for biomedical applications.

Basic Information

Product Name	Thiol-Peg3-Phosphonic Acid
CAS No.	1360716-36-4
Molecular Formula	C9H21NO7PS
Molecular Weight	309.30 g/mol
Synonyms	3-[2-[2-(3-Mercaptopropoxy)ethoxy]ethoxy]propylphosphonic acid; HS-PEG3-Phosphonic Acid; Thiol-PEG3-Phosphonate; (3-{2-[2-(3-Sulfanylpropoxy)ethoxy]ethoxy}propyl)phosphonic acid; 3,6,9-Trioxa-12-thia-15-phosphapentadecan-15-one 15-oxide; PEG3-Thiol-Phosphonic Acid; SH-PEG3-PA; 2-[2-[2-(3-Sulfanylpropoxy)ethoxy]ethoxy]ethylphosphonic acid (alternative representation)
EINECS	Contact for details

Quality Control

Our Thiol-Peg3-Phosphonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for functional group quantification, to ensure it meets the high standards required for research and commercial applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store the product in a freezer at -20°C to -10°C under an inert atmosphere (argon or nitrogen) to minimize oxidation of the thiol group and prevent moisture absorption. Allow the sealed container to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Thiol Titration)	≥ 90%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.