Description

2-tert-Butyl 1-Methyl 3,4-Dihydroisoquinoline-1,2(1H)-Dicarboxylate is a high-purity, protected dihydroisoquinoline derivative serving as a critical synthetic intermediate in advanced organic chemistry. This compound is valued for its role in constructing complex nitrogen-containing heterocycles, which are core scaffolds in numerous active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of tetrahydroisoquinoline-based drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that leverage the dihydroisoquinoline pharmacophore.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing specialty chemicals and complex organic molecules.
• Academic & Industrial R&D: Serves as a versatile starting material in methodological chemistry research for developing new synthetic routes and catalytic processes.
• Ligand & Catalyst Precursor: Potential use in the preparation of chiral ligands or organocatalysts for asymmetric synthesis applications.

Basic Information

Product Name	2-tert-Butyl 1-Methyl 3,4-Dihydroisoquinoline-1,2(1H)-Dicarboxylate
CAS No.	1359987-62-4
Molecular Formula	C16H21NO4
Molecular Weight	291.34 g/mol
Synonyms	1,2(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-2-(1,1-dimethylethyl) 1-methyl ester; 1-Methyl 2-tert-butyl 1,2,3,4-tetrahydroisoquinoline-1,2-dicarboxylate; 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid methyl ester; Methyl 2-((tert-butoxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylate; Boc-DHIQ-OMe; 1,2-Dicarbethoxy-1,2,3,4-tetrahydroisoquinoline derivative (protected); 2-Boc-1-COOMe-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our 2-tert-Butyl 1-Methyl 3,4-Dihydroisoquinoline-1,2(1H)-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be sensitive to prolonged exposure to moisture and should be handled under inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.