Description

(1Z,3Z)-1,3-Bis[[(4S)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]Methylene]-2,3-Dihydro-1H-Isoindole is a sophisticated chiral organic compound featuring a unique isoindole core symmetrically substituted with two (4S)-4-phenyl-4,5-dihydrooxazolyl (phenyl-oxazoline) moieties. This molecular architecture makes it a valuable non-racemic ligand precursor or building block for asymmetric synthesis and catalysis. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams developing novel chiral catalysts and advanced intermediates.

Application

• Chiral Ligand Synthesis: Serves as a key precursor for the development of novel, bidentate nitrogen-oxygen (N,O) or bis-oxazoline ligands used in asymmetric catalysis.
• Asymmetric Catalysis: Potential application in enantioselective transformations such as Diels-Alder reactions, cyclopropanations, and aldol additions when complexed with metals like copper, zinc, or palladium.
• Pharmaceutical Intermediates: Used in the research and development of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Material Science Research: Investigated as a building block for chiral organic frameworks (COFs) or polymers with specific optical properties.
• Academic & Industrial R&D: A valuable tool compound for studying structure-activity relationships in catalysis and exploring new synthetic methodologies.

Basic Information

Item	Details
Product Name	(1Z,3Z)-1,3-Bis[[(4S)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]Methylene]-2,3-Dihydro-1H-Isoindole
CAS No.	1358991-52-2
Molecular Formula	C30H24N2O2
Molecular Weight	444.53 g/mol
Synonyms	(1Z,3Z)-1,3-Bis[(4S)-4-phenyl-4,5-dihydro-1,3-oxazol-2-ylmethylene]-2,3-dihydro-1H-isoindole; (Z,Z)-1,3-Bis[[(4S)-4,5-dihydro-4-phenyl-2-oxazolyl]methylene]-2,3-dihydro-1H-isoindole; Bis[(4S)-4-phenyl-2-oxazolinyl]methylene-isoindoline derivative; Chiral bis(oxazoline) isoindole ligand precursor; (S,S)-Bis(PHOX)-Isoindole
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) detailing specifications such as enantiomeric excess (ee), HPLC purity, and NMR data are available upon request. We adhere to a cGMP-compliant quality management system for traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.