Description

1,1,1,3,3,3-Hexafluoro-2-(3-Fluoro-4-Iodophenyl)Propan-2-Ol (Wxfc0665) is a high-value, multi-fluorinated and iodinated aromatic building block, identified by CAS NO 1358953-45-3. This compound is critical for introducing unique steric and electronic properties into advanced molecular architectures, enabling the development of novel materials and active compounds. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials sectors for applications requiring precise structural modification and enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for introducing fluorine and iodine atoms to modulate bioavailability, metabolic stability, and receptor binding affinity.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides where the fluorinated and iodinated phenyl group contributes to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorine-containing aromatic cores in electronic materials, enhancing thermal stability, charge transport, and optical properties in display technologies.
• Polymer Modification: Employed to synthesize specialty monomers for high-performance polymers with increased chemical resistance, lower surface energy, and tailored refractive indices.
• Positron Emission Tomography (PET) Tracer Development: The iodine atom provides a handle for radioiodination, making it a potential precursor for developing diagnostic imaging agents.
• Cross-Coupling Reactions: The aryl iodide moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.

Basic Information

Product Name	1,1,1,3,3,3-Hexafluoro-2-(3-Fluoro-4-Iodophenyl)Propan-2-Ol (Wxfc0665)
CAS No.	1358953-45-3
Molecular Formula	C9H4F7IO
Molecular Weight	388.02 g/mol
Synonyms	Hexafluoro-2-(3-fluoro-4-iodophenyl)propan-2-ol; 2-(3-Fluoro-4-iodophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol; 1,1,1,3,3,3-Hexafluoro-2-(3-fluoro-4-iodophenyl)-2-propanol; Wxfc-0665; WXFC0665; HFIP-Iodophenyl Derivative; Perfluorinated Tertiary Alcohol Intermediate
EINECS	Contact for details

Quality Control

Every batch of 1,1,1,3,3,3-Hexafluoro-2-(3-Fluoro-4-Iodophenyl)Propan-2-Ol is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical R&D and scale-up processes. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC/NMR), related substances, and residual solvents are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.