Description

Spiro[Cyclopropane-1,3'-[3H]Indol]-2'(1'H)-One, 1'-(4-Piperidinyl)- is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic indole scaffold. This compound is valued for its structural complexity and its role as a critical building block in modern medicinal chemistry. It is primarily utilized by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation therapeutics.
• Chemical Biology Probes: Employed in the development of tool compounds for studying biological processes and target validation.
• Academic & Contract Research: Supplied to universities and CROs for fundamental research in organic synthesis and pharmacology.

Basic Information

Product Name	Spiro[Cyclopropane-1,3'-[3H]Indol]-2'(1'H)-One, 1'-(4-Piperidinyl)-
CAS No.	1358667-56-7
Molecular Formula	C15H18N2O
Molecular Weight	242.32 g/mol
Synonyms	1'-(4-Piperidinyl)spiro[cyclopropane-1,3'-indol]-2'(1'H)-one; 1'-(Piperidin-4-yl)-1'H-spiro[cyclopropane-1,3'-indol]-2'-one; 1-(Piperidin-4-yl)-1,2-dihydrospiro[indole-3,1'-cyclopropan]-2-one; Spiro[cyclopropane-1,3'-indole]-2'(1'H)-one, 1'-(4-piperidinyl)-; 1358667-56-7; 1'-(4-Piperidyl)spiro[cyclopropane-1,3'-indol]-2'(1'H)-one
EINECS	Contact for details

Quality Control

Our Spiro[Cyclopropane-1,3'-[3H]Indol]-2'(1'H)-One, 1'-(4-Piperidinyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (HPLC), related substances, and residual solvents. Our quality commitment supports compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccant or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.