Description

5-(Trifluoromethyl)-3-Methoxyisoquinoline is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethyl-substituted isoquinoline scaffold. This compound matters for its critical role in modern drug discovery, where the trifluoromethyl group is strategically employed to enhance metabolic stability, lipophilicity, and binding affinity of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the research and development of new drug candidates, particularly in oncology, CNS disorders, and anti-infective therapies.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethyl group contributes to improved efficacy and environmental profile.
• Material Science Research: Serves as a precursor for developing specialty chemicals, ligands, and functional materials with tailored electronic properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale manufacturing of complex molecules.

Basic Information

Product Name	5-(Trifluoromethyl)-3-Methoxyisoquinoline
CAS No.	1357945-68-6
Molecular Formula	C11H8F3NO
Molecular Weight	227.18 g/mol
Synonyms	3-Methoxy-5-(trifluoromethyl)isoquinoline; 5-(Trifluoromethyl)-3-methoxy-isoquinoline; Isoquinoline, 3-methoxy-5-(trifluoromethyl)-; 1357945-68-6; 3-Methoxy-5-trifluoromethylisoquinoline
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-3-Methoxyisoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports applications requiring high standards, including cGMP development and non-GMP research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.