Description

2-Chloro-6-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol is a high-value boronic ester derivative, a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone method for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of fluorinated and chlorinated drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific halogenated phenol backbones.
• Material Science: Serves as a monomer or precursor in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating complex molecular architectures.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a boronic ester coupling partner with aryl/vinyl halides to form biaryl and other conjugated systems.
• Protecting Group Strategy: The boronic ester group can act as a protected form of a boronic acid, offering improved stability for multi-step syntheses.

Basic Information

Product Name	2-Chloro-6-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol
CAS No.	1356953-67-7
Molecular Formula	C12H15BClFO3
Molecular Weight	271.51 g/mol
Synonyms	2-Chloro-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 4-Boronic acid, 2-chloro-6-fluoro-, 1,3,2-dioxaborolane ester; 2-Chloro-6-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; Phenol, 2-chloro-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1356953-67-7; 2-Chloro-6-fluoro-4-(pinacolatoboron)phenol; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloro-6-fluorophenol
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) detailing purity, identity, and impurity profiles via validated methods such as HPLC, NMR, and GC. Our quality commitment supports compliance with cGMP and ISO standards where required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis of the boronic ester group. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.