Description

L-(+)-Ergothioneine-D3 is a high-purity, deuterium-labeled isotopologue of the naturally occurring amino acid derivative L-Ergothioneine, serving as a critical internal standard for precise analytical quantification. This compound is essential for ensuring accuracy and reliability in mass spectrometry-based research, particularly in pharmacokinetic, metabolic, and biomarker studies. It is primarily utilized by analytical laboratories, pharmaceutical R&D teams, and nutraceutical manufacturers requiring definitive measurement of ergothioneine levels in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of endogenous L-Ergothioneine in biological fluids (plasma, serum, urine) and tissue samples, correcting for matrix effects and instrument variability.
• Pharmacokinetic & Metabolic Studies: Enables precise tracking of absorption, distribution, metabolism, and excretion (ADME) of ergothioneine in preclinical and clinical research.
• Biomarker Research & Validation: Used as a reference standard in developing and validating assays to study ergothioneine as a potential biomarker for oxidative stress, aging, or specific disease states.
• Nutraceutical & Dietary Supplement Analysis: Critical for quality control and potency verification in products containing ergothioneine, ensuring label claim accuracy and regulatory compliance.
• Food & Beverage Analysis: Employed to measure natural ergothioneine content in mushrooms, meat, and other dietary sources for nutritional profiling and research.
• Stable Isotope Dilution Assays: The deuterium label provides a mass shift, making it ideal for highly specific and sensitive stable isotope dilution methodologies.

Basic Information

Product Name	L-(+)-Ergothioneine-D3
CAS No.	1356933-89-5
Molecular Formula	C9H12D3N3O2S
Molecular Weight	232.31 g/mol (approx.)
Synonyms	L-Ergothioneine-d3; (S)-α-Carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-1H-imidazole-4-ethanaminium-d3 Hydroxide, Inner Salt; Deuterated L-Ergothioneine; EGT-d3; Thioneine-d3; 2-Mercaptohistidine Trimethylbetaine-d3; L-2-Thiolhistidine Betaine-d3
EINECS	Contact for details

Quality Control

Our L-(+)-Ergothioneine-D3 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity by HPLC, and confirmation of structure. We adhere to relevant guidelines for reference standard materials to ensure consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.