Description

n-(Acetyl-D3)-S-(3-Carboxy-2-Propyl)-L-Cysteine Disodium Salt is a stable, deuterated metabolite standard of the mercapturic acid pathway, essential for precise analytical quantification. This high-purity reference material is critical for ensuring accuracy and reliability in advanced mass spectrometry and chromatography-based assays. It is primarily required by pharmaceutical R&D, contract research organizations (CROs), and analytical laboratories for drug metabolism and pharmacokinetic (DMPK) studies, biomarker validation, and toxicological research.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative deuterated internal standard for the accurate measurement of its non-deuterated counterpart and related mercapturic acid metabolites in biological matrices.
• Drug Metabolism Studies (DMPK): Essential in tracing and quantifying specific metabolic pathways, particularly those involving glutathione conjugation (Phase II metabolism), to understand drug disposition and bioactivation.
• Biomarker Research & Validation: Serves as a critical calibrant in developing and validating assays for exposure biomarkers related to specific chemicals or toxicants.
• Toxicological & Safety Assessment: Enables precise measurement of metabolite levels in preclinical and clinical studies to assess toxicity and metabolic fate.
• Clinical Research: Supports studies investigating human exposure to environmental or occupational chemicals by providing a stable isotopic reference for high-sensitivity detection.
• Method Development & GLP Compliance: Provides a traceable and consistent reference point for developing robust analytical methods in compliance with Good Laboratory Practice (GLP) guidelines.

Basic Information

Product Name	n-(Acetyl-D3)-S-(3-Carboxy-2-Propyl)-L-Cysteine Disodium Salt
CAS No.	1356933-73-7
Molecular Formula	C11H14D3NNa2O5S
Molecular Weight	333.30 g/mol
Synonyms	N-Acetyl-S-(3-carboxypropyl)-L-cysteine-d3 disodium salt; N-Acetyl-S-(3-carboxypropyl)-L-cysteine (acetyl-d3) disodium salt; N-Acetyl-S-(3-carboxypropyl)cysteine-d3 disodium salt; L-Cysteine, N-[acetyl-2H3]-S-(3-carboxypropyl)-, disodium salt; Deuterated DHMBA mercapturate disodium salt; DHMBA-d3 Mercapturic Acid Disodium Salt; Internal Standard for DHMBA-MA
EINECS	Contact for details

Quality Control

Every batch of n-(Acetyl-D3)-S-(3-Carboxy-2-Propyl)-L-Cysteine Disodium Salt is manufactured under strict quality systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity suitable for sensitive analytical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (by HPLC), isotopic enrichment, and other critical parameters to support your research and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For extended storage, consider desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (deuterium, D)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 98%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.