Description

1-((2R)-2-Amino-2-Cyclohexylacetyl)-n-(4’-Cyanobenzyl)-2-L-Azetidinecarboxamide-D11 is a high-purity, deuterium-labeled compound designed for advanced research and development applications. This product is critical for scientists requiring stable isotope-labeled internal standards in quantitative mass spectrometry, ensuring superior accuracy and reproducibility in analytical workflows. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism and pharmacokinetics (DMPK) studies, proteomics, and biomarker discovery.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, isotopically labeled internal standard for the precise quantification of its non-deuterated counterpart in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Proteomic and Metabolomic Research: Used in stable isotope labeling techniques for the relative and absolute quantification of peptides, proteins, and small molecule metabolites.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants during drug substance development.
• Biomarker Validation: Provides a reliable reference for the development and validation of targeted assays to discover and verify disease biomarkers.
• Synthetic Chemistry Reference: Acts as a reference compound for synthetic chemists developing novel azetidine-based molecules or optimizing synthetic routes.

Basic Information

Product Name	1-((2R)-2-Amino-2-Cyclohexylacetyl)-n-(4’-Cyanobenzyl)-2-L-Azetidinecarboxamide-D11
CAS No.	1356930-51-2
Molecular Formula	C20H17D11N4O2
Molecular Weight	Contact for details
Synonyms	L-Azetidinecarboxamide, 1-[(2R)-2-amino-2-cyclohexylacetyl]-N-[(4-cyanophenyl)methyl]-, 11-d; Deuterated Azetidine Carboxamide Derivative; (2R)-2-Amino-2-cyclohexyl-N-[(4-cyanophenyl)methyl]-1-(2-oxo-1-azetidinyl)-1-oxoethanamine-d11; Stable Isotope Labeled Internal Standard 1356930-51-2; Azetidine-2-carboxamide-D11 derivative; D11-Labeled Cyclohexylglycine Azetidine Amide; 4'-Cyanobenzyl Azetidinecarboxamide-D11
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is produced and tested under strict quality management protocols to ensure the highest isotopic purity and chemical integrity. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as isotopic purity (D-enrichment), chemical purity (HPLC), and identity confirmation (NMR, MS). Our quality systems are designed to meet the rigorous demands of analytical and pharmaceutical research, ensuring reliable and reproducible performance in your sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); containers should be allowed to equilibrate to room temperature before opening to minimize moisture ingress. For extended storage under an inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.