Description

1-(Phenylsulfonyl)-1H-Indole-4-Carboxylic Acid is a high-purity, synthetically valuable organic building block characterized by its indole core functionalized with both a phenylsulfonyl group and a carboxylic acid moiety. This compound is of significant importance in modern pharmaceutical and agrochemical research as a versatile intermediate for constructing complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for applications in medicinal chemistry and advanced material synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its modifiable functional groups.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new-generation pesticides and herbicides.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination, to create complex heterocyclic systems.
• Chemical Biology Probe Synthesis: Useful for creating molecular probes to study biological pathways and protein functions.
• Material Science Research: Potential monomer or precursor for specialty polymers and advanced organic materials with specific electronic properties.

Basic Information

Item	Details
Product Name	1-(Phenylsulfonyl)-1H-Indole-4-Carboxylic Acid
CAS No.	1356470-08-0
Molecular Formula	C15H11NO4S
Molecular Weight	301.32 g/mol
Synonyms	1H-Indole-4-carboxylic acid, 1-(phenylsulfonyl)-; 4-Carboxy-1-(phenylsulfonyl)indole; 1-Benzenesulfonyl-1H-indole-4-carboxylic acid; 1-(Phenylsulfonyl)indole-4-carboxylic acid; 1-Phenylsulfonylindole-4-carboxylic acid; 1356470-08-0; 1-(Benzenesulfonyl)-1H-indole-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulfonyl)-1H-Indole-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure stability. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.