Description

N,N'-Diacetyl-L-Cystine Bis(tert-Butyl) Diester-D6 is a deuterated, protected derivative of the amino acid L-cysteine, specifically designed for advanced research and development applications. This compound is critical for studies requiring isotopic labeling, such as metabolic pathway tracing, pharmacokinetic analysis, and the development of high-precision analytical methods. It is primarily utilized by pharmaceutical researchers, analytical chemists, and isotope labeling specialists working in drug discovery and proteomics.

Application

• Isotopic Internal Standard for LC-MS/MS: Serves as a crucial quantitative standard in mass spectrometry for the accurate measurement of cysteine and its derivatives in complex biological matrices.
• Metabolic Pathway Tracing: Used in deuterium-labeling studies to investigate the metabolic fate and transformation of sulfur-containing amino acids in vivo and in vitro.
• Pharmaceutical Intermediate: Acts as a protected, labeled building block in the synthesis of deuterated drug candidates, peptides, or prodrugs for enhanced stability or tracking.
• Proteomics and Biomarker Research: Employed in the development of isotope-coded affinity tags (ICAT) or other labeling strategies for comparative protein quantification.
• Analytical Method Development: Essential for validating and calibrating new analytical methods (HPLC, GC-MS) designed to detect and quantify thiol-based compounds.
• Stability and Degradation Studies: Utilized to study the oxidative stability and degradation pathways of cysteine-containing compounds under various conditions.

Basic Information

Product Name	N,N'-Diacetyl-L-Cystine Bis(tert-Butyl) Diester-D6
CAS No.	1356382-52-9
Molecular Formula	C18H26D6N2O6S2
Molecular Weight	~430.6 g/mol
Synonyms	L-Cystine, N,N'-diacetyl-, bis(1,1-dimethylethyl) ester, D6; Diacetylcystine di-tert-butyl ester-D6; Bis(tert-butyl) N,N'-diacetyl-L-cystinate-D6; Deuterated Diacetyl Cystine tert-Butyl Ester; (2R,2'R)-3,3'-Disulfanediylbis(2-(acetylamino)propanoic acid) bis(tert-butyl) ester-D6; Ac-Cys(StBu)-OH-D6 (common abbreviation); Protected L-Cystine-D6 derivative
EINECS	Contact for details

Quality Control

Our N,N'-Diacetyl-L-Cystine Bis(tert-Butyl) Diester-D6 is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, isotopic enrichment, and structural identity. Certificates of Analysis (COA) detailing specifications such as isotopic purity (D-enrichment), chemical purity by HPLC, and identity confirmation by NMR and MS are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.