Description

Prostaglandin E2-D9 is a high-purity, deuterium-labeled analog of Prostaglandin E2 (PGE2), a key bioactive lipid mediator. This stable isotope-labeled compound is essential for precise quantitative analysis in biomedical research, providing unmatched accuracy in mass spectrometry-based assays. It is primarily utilized by pharmaceutical R&D teams, clinical research organizations, and analytical laboratories focused on inflammation, oncology, and reproductive biology studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for the accurate measurement of endogenous PGE2 levels in complex biological matrices.
• Metabolic Pathway Tracing: Used in deuterium tracing studies to investigate the biosynthesis, turnover, and metabolic fate of prostaglandins in cell cultures and animal models.
• Drug Discovery & Development: Supports pharmacokinetic (PK) and pharmacodynamic (PD) studies for novel anti-inflammatory and analgesic compounds targeting the cyclooxygenase pathway.
• Clinical Biomarker Research: Enables the development and validation of highly sensitive assays for PGE2 as a biomarker in various disease states, including cancer and chronic inflammation.
• Quality Control in Pharma: Employed as a certified reference material for the quality control and potency testing of prostaglandin-based pharmaceutical products.
• Academic Research: Facilitates fundamental research in physiology and pharmacology to elucidate the role of PGE2 in pain signaling, fever, and smooth muscle contraction.

Basic Information

Product Name	Prostaglandin E2-D9
CAS No.	1356347-42-6
Molecular Formula	C₂₀H₂₃D₉O₅
Molecular Weight	357.5 g/mol (approx.)
Synonyms	PGE2-d9; Dinoprostone-d9; (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic-3,3,4,4,5,5,6,6,7-d9 Acid; Deuterated Prostaglandin E2; Prostaglandin E2 (deuterated); 11-Deoxy-13,14-dihydro-15-keto Prostaglandin E2-d9; PG E2-d9
EINECS	Contact for details

Quality Control

Every batch of Prostaglandin E2-D9 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical purity and MS for isotopic enrichment. A detailed Certificate of Analysis (COA), providing batch-specific data, is supplied with each shipment to ensure full traceability and compliance with your research or quality control protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This compound is strictly light-sensitive (protect from all light exposure) and hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Solubility	Soluble in ethanol, DMSO; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.