Description

trans-Ethyl 3-(1,3-Dioxoisoindolin-2-Yl)Cyclobutanecarboxylate CAS NO 1356089-94-5 is a high-purity, advanced pharmaceutical intermediate featuring a cyclobutane core fused with a phthalimide moiety. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile scaffold for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating novel therapeutic agents, particularly in the areas of protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially those targeting enzymatic pathways.
• Protease Inhibitor Development: Used in research for creating potential inhibitors for diseases where protease activity is a factor.
• Medicinal Chemistry Research: Provides a constrained, fused-ring scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to introduce the phthalimide-protected amine and ester functional groups.
• Academic Research: Utilized in university and institutional labs for studying cyclobutane chemistry and heterocyclic compound reactivity.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharma and biotech industries.

Basic Information

Product Name	trans-Ethyl 3-(1,3-Dioxoisoindolin-2-Yl)Cyclobutanecarboxylate
CAS No.	1356089-94-5
Molecular Formula	C15H15NO4
Molecular Weight	273.28 g/mol
Synonyms	Ethyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)cyclobutanecarboxylate (trans-); trans-2-(3-Ethoxycarbonylcyclobutyl)isoindoline-1,3-dione; 2-[3-(Ethoxycarbonyl)cyclobutyl]-1H-isoindole-1,3(2H)-dione; 1,3-Dioxoisoindoline-2-cyclobutanecarboxylic Acid Ethyl Ester (trans-); trans-1,3-Dioxo-2-(3-ethoxycarbonylcyclobutyl)isoindoline; Cyclobutanecarboxylic acid, 3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, ethyl ester, trans-; (1r,3r)-Ethyl 3-(1,3-dioxoisoindolin-2-yl)cyclobutanecarboxylate
EINECS	Contact for details

Quality Control

Our trans-Ethyl 3-(1,3-Dioxoisoindolin-2-Yl)Cyclobutanecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.