Description

Methyl 3-Bromo-5-Iodothiophene-2-Carboxylate is a high-purity, multi-halogenated thiophene derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its unique reactivity profile, enabling the precise construction of complex heterocyclic systems. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the thiophene scaffold's bioactivity.
• Organic Electronic Materials: Serves as a monomer or building block for π-conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), field-effect transistors (OFETs), and solar cells.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The bromo and iodo substituents make it an excellent substrate for sequential Suzuki, Stille, and Sonogashira cross-coupling reactions to create diverse biaryl and extended structures.
• Chemical Biology Probes: Used to synthesize tagged molecules or probes for studying biological pathways and protein interactions.

Basic Information

Product Name	Methyl 3-Bromo-5-Iodothiophene-2-Carboxylate
CAS No.	1355039-67-6
Molecular Formula	C6H4BrIO2S
Molecular Weight	346.97 g/mol
Synonyms	3-Bromo-5-iodothiophene-2-carboxylic acid methyl ester; Methyl 3-bromo-5-iodo-2-thiophenecarboxylate; 2-Thiophenecarboxylic acid, 3-bromo-5-iodo-, methyl ester; 3-Bromo-5-iodothiophene-2-methyl carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 3-Bromo-5-Iodothiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization including HPLC for purity, NMR (1H & 13C) and IR for structural confirmation, and MS for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.