Description

6,6-Difluoro-2-Aza-Spiro[3.3]Heptane Trifluoroacetate is a high-value, fluorinated spirocyclic building block of significant interest in modern pharmaceutical and agrochemical research. Its unique rigid scaffold, featuring a nitrogen atom and two fluorine atoms, makes it a critical intermediate for constructing novel bioactive molecules with enhanced metabolic stability and binding affinity. This compound is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical industry for the synthesis of advanced drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting G protein-coupled receptors (GPCRs) and kinases.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and scaffold hopping to improve the pharmacokinetic properties (e.g., metabolic stability, membrane permeability) of drug-like molecules.
• Agrochemical Research: Serves as a precursor in the development of new generation herbicides and pesticides, leveraging the fluorine atoms for enhanced bioactivity and environmental persistence.
• Chemical Biology Probe Development: Incorporated into molecular probes to study enzyme function and protein-ligand interactions due to its spirocyclic constraint and fluorine NMR tags.
• Material Science Precursor: Potential use in the synthesis of specialized fluorinated polymers or ligands for catalysis.

Basic Information

Product Name	6,6-Difluoro-2-Aza-Spiro[3.3]Heptane Trifluoroacetate
CAS No.	1354952-05-8
Molecular Formula	C8H10F5NO2
Molecular Weight	247.16 g/mol
Synonyms	6,6-Difluoro-2-azaspiro[3.3]heptane trifluoroacetate; 2-Azaspiro[3.3]heptane, 6,6-difluoro-, trifluoroacetate; 6,6-Difluoro-2-azaspiro[3.3]heptane TFA salt; 6,6-Difluoro-2-aza-spiro[3.3]heptane trifluoroacetic acid salt; Difluoroaza-spiro[3.3]heptane TFA; DFASH TFA
EINECS	Contact for details

Quality Control

Our 6,6-Difluoro-2-Aza-Spiro[3.3]Heptane Trifluoroacetate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and development. We provide comprehensive analytical data including HPLC purity, NMR (1H, 13C, 19F), and mass spectrometry for identity and quality verification. A detailed Certificate of Analysis (COA) is supplied with each batch, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.