Description

Laquinimod-D5 Sodium Salt is a deuterated isotopologue of the sodium salt form of Laquinimod, a compound of significant interest in pharmaceutical research and development. This stable isotope-labeled compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, such as Liquid Chromatography-Mass Spectrometry (LC-MS/MS), ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for researchers and analytical laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require high-purity reference materials for drug development programs.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application as a high-purity, stable isotope-labeled internal standard for the precise quantification of Laquinimod in biological matrices (plasma, serum, tissue).
• Pharmacokinetic (PK) and Toxicokinetic (TK) Studies: Enables accurate measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Metabolite Identification and Profiling: Aids in the structural elucidation and quantification of drug metabolites using mass spectrometry.
• Bioanalytical Method Development and Validation: Critical for developing robust, sensitive, and regulatory-compliant analytical methods for drug candidates.
• Drug Impurity and Degradation Product Analysis: Used as a reference marker in stability-indicating methods to monitor drug purity and stability.
• Regulatory Submissions: Supports data packages for regulatory filings (e.g., FDA, EMA) by providing traceable and reliable quantitative data.

Basic Information

Product Name	Laquinimod-D5 Sodium Salt
CAS No.	1354744-14-1
Molecular Formula	C19H12D5ClN2O3•Na
Molecular Weight	~ 389.8 g/mol
Synonyms	N-Ethyl-N-hydroxy-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide-D5 Sodium Salt; ABR-215062-D5 Sodium Salt; 5-Chloro-1-methyl-4-oxo-3-[(2H5)ethylcarbamoyl]-1,2-dihydroquinolin-1-ium-4-olate Sodium Salt; Laquinimod-d5 Sodium; Deuterated Laquinimod Sodium Salt; Laquinimod (ethyl-d5) Sodium Salt; Sodequinimod-D5
EINECS	Contact for details

Quality Control

Every batch of our Laquinimod-D5 Sodium Salt is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity suitable for sensitive analytical applications. Comprehensive testing includes identity confirmation, assay determination, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for purity (by HPLC), isotopic enrichment (by MS), and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5)	≥ 98.0 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.