Description

1-Difluoromethyl-4-Iodo-5-Methyl-3-Nitro-1H-Pyrazole is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound matters for its unique molecular architecture, which combines halogen, nitro, and difluoromethyl groups to enable precise structural modifications in complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, leveraging its halogen and nitro substituents for bioactivity.
• Material Science Research: Serves as a precursor for functionalized polymers or ligands in catalytic systems due to its reactive pyrazole core.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds or probes for studying biological pathways and target engagement.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to build complex molecular architectures.
• Fluorine Chemistry: The difluoromethyl group provides a metabolically stable bioisostere, crucial for optimizing the pharmacokinetic properties of lead compounds.

Basic Information

Product Name	1-Difluoromethyl-4-Iodo-5-Methyl-3-Nitro-1H-Pyrazole
CAS No.	1354704-38-3
Molecular Formula	C5H4F2IN3O2
Molecular Weight	314.99 g/mol
Synonyms	4-Iodo-5-methyl-3-nitro-1-(difluoromethyl)-1H-pyrazole; 1H-Pyrazole, 1-(difluoromethyl)-4-iodo-5-methyl-3-nitro-; 1-(Difluoromethyl)-4-iodo-5-methyl-3-nitropyrazole; 4-Iodo-1-(difluoromethyl)-5-methyl-3-nitro-1H-pyrazole; DFMINP
EINECS	Contact for details

Quality Control

Our 1-Difluoromethyl-4-Iodo-5-Methyl-3-Nitro-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and ISO-guided processes ensures reliable supply for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination. Store away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.