Description

3-Methyl-Thiophene-2-Carboxylic Acid (S)-Pyrrolidin-3-Ylamide Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. This compound matters for its role in the synthesis of complex molecules, particularly in medicinal chemistry where its specific stereochemistry and functional groups are critical for biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and other therapeutic targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its defined stereochemistry and thiophene scaffold.
• Chemical Synthesis: Serves as a versatile building block for constructing more complex heterocyclic compounds and amide derivatives.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	3-Methyl-Thiophene-2-Carboxylic Acid (S)-Pyrrolidin-3-Ylamide Hydrochloride
CAS No.	1354018-51-1
Molecular Formula	C11H17ClN2OS
Molecular Weight	260.78 g/mol
Synonyms	(S)-3-Methylthiophene-2-carboxylic acid pyrrolidin-3-ylamide hydrochloride; (S)-N-(Pyrrolidin-3-yl)-3-methylthiophene-2-carboxamide hydrochloride; 3-Methylthiophene-2-carboxylic acid (S)-3-aminopyrrolidine-1-carboxamide hydrochloride; 1354018-51-1; (S)-Pyrrolidin-3-yl 3-methylthiophene-2-carboxamide hydrochloride; 3-Methyl-2-thiophenecarboxylic acid (3S)-3-aminopyrrolidine hydrochloride salt
EINECS	Contact for details

Quality Control

Our 3-Methyl-Thiophene-2-Carboxylic Acid (S)-Pyrrolidin-3-Ylamide Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical intermediates, and we can support development toward cGMP compliance as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.