Description

Thiophene-2-Carboxylic Acid(R)-Pyrrolidin-3-Ylamide Hydrochloride is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because it provides a critical, structurally defined building block for the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by research and development organizations and production facilities in the pharmaceutical and biotechnology sectors, where it is utilized in the creation of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and commercial synthesis of novel drug candidates.
• API Development: Used as a building block in the construction of complex molecules for potential therapeutic applications.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes.
• Asymmetric Synthesis: Utilized in chiral pool synthesis and the preparation of enantiomerically pure compounds.
• Preclinical & Clinical Trial Material Production: Supplied for the manufacture of compounds required for non-clinical and clinical development stages.
• Contract Manufacturing (CMO): Sourced by contract research and manufacturing organizations for client-specific synthesis projects.

Basic Information

Product Name	Thiophene-2-Carboxylic Acid(R)-Pyrrolidin-3-Ylamide Hydrochloride
CAS No.	1354010-59-5
Molecular Formula	C10H15ClN2OS
Molecular Weight	246.75 g/mol
Synonyms	(R)-N-(Pyrrolidin-3-yl)thiophene-2-carboxamide hydrochloride; (R)-Thiophene-2-carboxylic acid pyrrolidin-3-ylamide hydrochloride; (3R)-N-(Pyrrolidin-3-yl)thiophene-2-carboxamide hydrochloride; (R)-3-(Thiophene-2-carboxamido)pyrrolidine hydrochloride; Pyrrolidine, 3-[(2-thienylcarbonyl)amino]-, hydrochloride, (3R)-; 1354010-59-5; Thiophene-2-carboxamide, N-[(3R)-3-pyrrolidinyl]-, hydrochloride
EINECS	Contact for details

Quality Control

Our Thiophene-2-Carboxylic Acid(R)-Pyrrolidin-3-Ylamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.