Description

(R)-3-Hydroxy-Pyrrolidin-1-Yl)-(3-Methyl-Thiophen-2-Yl)-Methanone is a high-purity chiral building block of significant interest in advanced organic synthesis. Its value lies in its unique molecular architecture, which incorporates both a pyrrolidine scaffold and a thiophene moiety, making it a versatile intermediate for constructing complex pharmacologically active molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for neurological and psychiatric disorders.
• Asymmetric Synthesis: Used as a precursor or ligand in catalytic asymmetric reactions to introduce stereochemical complexity.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study biological pathways and enzyme functions.
• Agrochemical Development: Potential intermediate in the synthesis of advanced, chiral agrochemicals requiring specific biological activity.
• Academic Research: Employed in university and institutional labs for methodological development in organic and heterocyclic chemistry.

Basic Information

Product Name	(R)-3-Hydroxy-Pyrrolidin-1-Yl)-(3-Methyl-Thiophen-2-Yl)-Methanone
CAS No.	1354009-00-9
Molecular Formula	C10H13NO2S
Molecular Weight	211.28 g/mol
Synonyms	(R)-[3-Hydroxy-1-pyrrolidinyl](3-methyl-2-thienyl)methanone; (3-Methylthiophen-2-yl)[(3R)-3-hydroxypyrrolidin-1-yl]methanone; (R)-3-Hydroxy-1-(3-methylthiophene-2-carbonyl)pyrrolidine; (R)-N-(3-Methylthiophen-2-yl)-3-hydroxypyrrolidine-1-carboxamide (tautomeric form); CAS 1354009-00-9; (R)-3-Hydroxy-Pyrrolidin-1-Yl)-(3-Methyl-Thiophen-2-Yl)-Methanone; (R)-enantiomer of the pyrrolidinyl thiophene ketone.
EINECS	Contact for details

Quality Control

Our (R)-3-Hydroxy-Pyrrolidin-1-Yl)-(3-Methyl-Thiophen-2-Yl)-Methanone is produced under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), chiral purity (>99% ee), and impurity profiles. We adhere to cGMP guidelines where applicable for pharmaceutical intermediates, ensuring reliable supply and traceability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.