Description

4-Bromo-1-Chloro-2-Cyclopropylbenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, chlorine, and a cyclopropyl substituent on a benzene ring, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions, medicinal chemistry, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the reactivity of its halogen atoms.
• Material Science Research: Serves as a building block for creating specialized organic ligands, liquid crystals, and advanced polymeric materials.
• Cross-Coupling Reactions: The bromine substituent is highly reactive in palladium-catalyzed couplings (e.g., Suzuki, Heck, Sonogashira) for carbon-carbon bond formation.
• Medicinal Chemistry & SAR Studies: The cyclopropyl group is a valuable bioisostere used to modulate the potency, metabolic stability, and physicochemical properties of drug candidates.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions.

Basic Information

Product Name	4-Bromo-1-Chloro-2-Cyclopropylbenzene
CAS No.	1353855-70-5
Molecular Formula	C9H8BrCl
Molecular Weight	231.52 g/mol
Synonyms	1-Bromo-4-Chloro-2-Cyclopropylbenzene; 2-Cyclopropyl-4-Bromochlorobenzene; 4-Bromo-2-Cyclopropylchlorobenzene; 2-Cyclopropyl-1-Chloro-4-Bromobenzene; (4-Bromo-2-chlorophenyl)cyclopropane; 1-Chloro-4-bromo-2-cyclopropylbenzene
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-1-Chloro-2-Cyclopropylbenzene is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), identity confirmation (IR, NMR), and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.