Description

2-Methyl-3-Nitro-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridine is a high-value, multi-functional heterocyclic building block, specifically a pyridine boronic ester derivative. This compound is essential for advanced organic synthesis, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction, enabling the precise construction of complex molecular architectures. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in drug discovery for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with improved efficacy.
• Material Science & OLED Development: Serves as a precursor for creating organic light-emitting diode (OLED) materials and other advanced electronic chemicals.
• Ligand & Catalyst Design: Employed in the synthesis of sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): A valuable handle for constructing bifunctional molecules used in targeted protein degradation research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring precise boronic ester functionality.

Basic Information

Product Name	2-Methyl-3-Nitro-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridine
CAS No.	1353715-51-1
Molecular Formula	C12H17BN2O4
Molecular Weight	264.09 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methyl-3-nitropyridine; 2-Methyl-3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Nitro-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pyridine, 2-methyl-3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 2-Methyl-3-nitro-5-pyridineboronic acid pinacol ester; 5-Pinacolatoboryl-2-methyl-3-nitropyridine
EINECS	Contact for details

Quality Control

Our 2-Methyl-3-Nitro-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, keep under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C (refrigerated). The compound is moisture-sensitive; allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.