Description

n-(4-(4-Methylpiperazin-1-Yl)Phenyl)-4-(3-Nitrophenoxy)Thieno[3,2-D]Pyrimidin-2-Amine CAS NO 1353553-08-8 is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel kinase inhibitors and targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and contract research organizations (CROs) focused on oncology and signal transduction pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel small-molecule drug candidates targeting specific kinases.
• Oncology Research: Used in the development of potential anti-cancer agents due to its thienopyrimidine core, a privileged scaffold in kinase inhibition.
• Biochemical Screening: Serves as a reference standard or a lead compound in high-throughput screening (HTS) assays for drug discovery.
• Medicinal Chemistry Studies: Employed in structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and molecular pharmacology.

Basic Information

Product Name	n-(4-(4-Methylpiperazin-1-Yl)Phenyl)-4-(3-Nitrophenoxy)Thieno[3,2-D]Pyrimidin-2-Amine
CAS No.	1353553-08-8
Molecular Formula	C23H22N6O3S
Molecular Weight	462.52 g/mol
Synonyms	4-(3-Nitrophenoxy)-N-[4-(4-methyl-1-piperazinyl)phenyl]thieno[3,2-d]pyrimidin-2-amine; Thieno[3,2-d]pyrimidin-2-amine, 4-(3-nitrophenoxy)-N-[4-(4-methyl-1-piperazinyl)phenyl]-; 1353553-08-8; UNII-8V3C8XJ6QN; 8V3C8XJ6QN; CHEMBL3186660; BDBM50157857; AKOS025147065
EINECS	Contact for details

Quality Control

Every batch of this pharmaceutical intermediate is produced under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with the standards expected for GMP-grade intermediates used in research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to brown solid powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.