Description

1H-Indole-4-Carboxylic Acid, 6-(Trifluoromethyl)-, Methyl Ester is a high-value trifluoromethylated indole derivative, a crucial building block in modern organic synthesis. Its molecular structure makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and advanced agrochemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for its role in creating compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Material Science Research: Serves as a precursor for functional organic materials, including organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology & Proteomics: Employed as a molecular probe or labeling agent due to its unique indole scaffold and fluorine tags.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.
• Custom Synthesis & Scale-Up: A starting material for contract manufacturing organizations (CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	1H-Indole-4-Carboxylic Acid, 6-(Trifluoromethyl)-, Methyl Ester
CAS No.	1352905-52-2
Molecular Formula	C11H8F3NO2
Molecular Weight	243.18 g/mol
Synonyms	Methyl 6-(trifluoromethyl)-1H-indole-4-carboxylate; 6-(Trifluoromethyl)-1H-indole-4-carboxylic acid methyl ester; 1H-Indole-4-carboxylic acid, 6-(trifluoromethyl)-, methyl ester; Methyl 6-trifluoromethylindole-4-carboxylate; 6-Trifluoromethyl-1H-indole-4-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1H-Indole-4-Carboxylic Acid, 6-(Trifluoromethyl)-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.