Description

Ethyl 7-Chloro-5-Nitro-1H-Indole-2-Carboxylate is a high-purity, synthetically versatile indole derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a functionalized indole core, enabling the efficient construction of complex molecules for pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and R&D professionals developing novel active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and anticancer compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactive indole scaffold.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and other transformations to introduce complex indole motifs.
• Material Science: Potential intermediate for creating functional organic materials, such as organic light-emitting diodes (OLEDs) or conductive polymers.
• Academic & Contract Research: Serves as a valuable reagent for universities and CROs (Contract Research Organizations) conducting exploratory chemistry and method development.

Basic Information

Product Name	Ethyl 7-Chloro-5-Nitro-1H-Indole-2-Carboxylate
CAS No.	1352899-64-9
Molecular Formula	C11H9ClN2O4
Molecular Weight	268.65 g/mol
Synonyms	7-Chloro-5-nitro-1H-indole-2-carboxylic acid ethyl ester; Ethyl 7-chloro-5-nitroindole-2-carboxylate; 1H-Indole-2-carboxylic acid, 7-chloro-5-nitro-, ethyl ester; 2-Carbethoxy-7-chloro-5-nitroindole; 7-Chloro-5-nitroindole-2-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 7-Chloro-5-Nitro-1H-Indole-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.