Description

Benzenemethanol, 6-Bromo-2-Fluoro-3-(Trifluoromethyl)- is a highly functionalized benzyl alcohol derivative, distinguished by its unique halogen and trifluoromethyl substitution pattern. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry, enabling the introduction of complex aromatic motifs. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a building block for developing new-generation herbicides, fungicides, and insecticides, where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Used in the research and production of specialty chemicals for electronic displays and organic light-emitting diodes (OLEDs), contributing to improved performance and efficiency.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct complex biaryl systems.
• Fluorine Chemistry Research: An important reagent for studying structure-activity relationships (SAR) in medicinal chemistry, leveraging the properties of the trifluoromethyl and fluorine groups.
• Polymer Modification: Acts as a functional monomer or modifier to introduce halogenated aromatic units into polymer chains, altering thermal and chemical resistance properties.

Basic Information

Product Name	Benzenemethanol, 6-Bromo-2-Fluoro-3-(Trifluoromethyl)-
CAS No.	1352718-85-4
Molecular Formula	C8H5BrF4O
Molecular Weight	273.03 g/mol
Synonyms	6-Bromo-2-fluoro-3-(trifluoromethyl)benzyl alcohol; (6-Bromo-2-fluoro-3-(trifluoromethyl)phenyl)methanol; 2-Fluoro-6-bromo-α-(trifluoromethyl)benzenemethanol; 3-(Bromomethyl)-2-fluoro-α,α,α-trifluorotoluene (tautomer); Benzenemethanol, 6-bromo-2-fluoro-3-(trifluoromethyl)-; 6-Bromo-2-fluoro-3-trifluoromethylbenzyl alcohol
EINECS	Contact for details

Quality Control

Our production of Benzenemethanol, 6-Bromo-2-Fluoro-3-(Trifluoromethyl)- adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical parameters. Our quality system is designed to support cGMP compliance for pharmaceutical applications and meets the rigorous standards required for global regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is sensitive to light and should be handled under appropriate conditions to prevent decomposition. Keep away from strong bases and fluorides. For long-term storage, consider inert atmosphere packing to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.