Description

6-Chloro-3-Fluoro-5-Azaindole is a high-value, multi-functional heterocyclic building block essential for modern pharmaceutical and agrochemical research. Its unique fused-ring structure, featuring strategically placed chlorine and fluorine substituents, makes it a critical intermediate for the synthesis of novel bioactive compounds. This product is primarily targeted at R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors seeking to develop new active ingredients with optimized properties.

Application

• Pharmaceutical Intermediate: A key scaffold in the synthesis of kinase inhibitors, receptor antagonists, and other small-molecule drug candidates, leveraging the fluorine atom for improved metabolic stability and membrane permeability.
• Agrochemical Synthesis: Serves as a precursor for developing new herbicides, fungicides, and insecticides, where the chloro-fluoro-azaindole core can contribute to novel modes of action.
• Chemical Biology Probe Development: Used in medicinal chemistry to create tool compounds for target validation and pathway analysis in biological systems.
• Material Science Research: Investigated as a building block for organic electronic materials and photoactive compounds due to its electron-deficient aromatic system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	6-Chloro-3-Fluoro-5-Azaindole
CAS No.	1352395-98-2
Molecular Formula	C7H4ClFN2
Molecular Weight	170.57 g/mol
Synonyms	6-Chloro-3-fluoro-1H-pyrrolo[2,3-b]pyridine; 3-Fluoro-6-chloro-1H-pyrrolo[2,3-b]pyridine; 6-Chloro-3-fluoro-7-azaindole; 3-Fluoro-6-chloro-7-azaindole; 6-Chloro-3-fluoro-1H-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-3-fluoro-; 6-Chloro-3-fluoro-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 6-Chloro-3-Fluoro-5-Azaindole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.