Description

2-(Piperazin-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester is a high-value boronic ester derivative, a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex heterocyclic compounds for drug discovery and development, especially for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection chemicals and herbicides.
• Material Science Research: Serves as a building block for creating novel organic electronic materials and functional polymers.
• Chemical Biology Probes: Employed in the development of molecular probes and diagnostic agents due to its versatile coupling capability.
• Catalyst Ligand Synthesis: A starting material for the preparation of specialized ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific boronic acid derivatives.

Basic Information

Product Name	2-(Piperazin-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	1351990-53-8
Molecular Formula	C14H23BN4O2
Molecular Weight	290.17 g/mol
Synonyms	2-(Piperazin-1-yl)pyrimidine-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(piperazin-1-yl)pyrimidine; 2-Piperazin-1-ylpyrimidine-5-boronic acid pinacol ester; 2-(1-Piperazinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 1351990-53-8; BRN 19153768
EINECS	Contact for details

Quality Control

Our 2-(Piperazin-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.