Description

2-Piperidin-1-Yl-Thiazole-5-Boronic Acid Pinacol Ester is a high-value boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing drug candidates, especially those containing heterocyclic scaffolds like thiazoles and piperidines, which are prevalent in CNS, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the thiazole moiety often contributes to biological activity.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, ligands for catalysis, and functional polymers through cross-coupling reactions.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tool compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic Research: Facilitates methodological development in synthetic organic chemistry and the exploration of new chemical space within university and institutional labs.

Basic Information

Product Name	2-Piperidin-1-Yl-Thiazole-5-Boronic Acid Pinacol Ester
CAS No.	1350755-62-2
Molecular Formula	C14H23BN2O2S
Molecular Weight	294.22 g/mol
Synonyms	2-(1-Piperidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 2-(Piperidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(1-piperidinyl)thiazole; 2-Piperidin-1-yl-thiazole-5-boronic acid pinacol ester; 2-(1-Piperidinyl)thiazole-5-boronic acid pinacol ester; Thiazole boronic ester derivative CAS 1350755-62-2
EINECS	Contact for details

Quality Control

Every batch of 2-Piperidin-1-Yl-Thiazole-5-Boronic Acid Pinacol Ester is manufactured and tested under strict quality management protocols to ensure consistency and reliability for critical R&D and scale-up processes. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.