Description

trans-2-Methyl-Cyclopropyl Boronic Acid Pinacol Ester is a high-value, organoboron building block crucial for modern synthetic chemistry, particularly in cross-coupling reactions. Its primary value lies in enabling the efficient and stereoselective introduction of the substituted cyclopropyl moiety into complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing novel active pharmaceutical ingredients (APIs), especially those containing cyclopropane rings known for metabolic stability.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the cyclopropyl group can enhance biological activity and environmental profile.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs, where precise structural control is paramount.
• Chemical Biology Probes: Utilized to create tagged molecules or inhibitors for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds at various scales.

Basic Information

Item	Details
Product Name	trans-2-Methyl-Cyclopropyl Boronic Acid Pinacol Ester
CAS No.	1350713-20-0
Molecular Formula	C11H21BO2
Molecular Weight	196.10 g/mol
Synonyms	trans-2-Methylcyclopropane-1-boronic acid pinacol ester; (1R,2S)-2-Methylcyclopropane-1-boronic acid pinacol ester (and its enantiomer); 2-Methylcyclopropylboronic acid pinacol ester; B-(trans-2-Methylcyclopropyl)boronic acid pinacol ester; trans-2-Methylcyclopropylboronic acid pinacol ester; Pinacol trans-2-methylcyclopropylboronate
EINECS	Contact for details

Quality Control

Every batch of trans-2-Methyl-Cyclopropyl Boronic Acid Pinacol Ester is manufactured under strict quality management systems. We employ advanced analytical techniques including GC, HPLC, and NMR to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) with full batch-specific data are provided and available upon request, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Isomeric Purity (trans-)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.