Description

n-(4-Chlorophenyl)-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is a high-purity boronic ester derivative, a critical advanced intermediate in modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and agrochemical research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries seeking to construct complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific biphenyl or heterobiaryl structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and tool compounds for target identification and validation studies.
• Academic & Contract Research: A vital reagent for methodology development and complex molecule synthesis in academic laboratories and CROs (Contract Research Organizations).
• Scale-up Process Development: Supports process chemistry teams in optimizing coupling reactions for pilot plant and commercial-scale manufacturing.

Basic Information

Product Name	n-(4-Chlorophenyl)-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	1350643-83-2
Molecular Formula	C18H22BClN2O2
Molecular Weight	344.64 g/mol
Synonyms	4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-chlorophenyl)pyridin-2-amine; 2-Amino-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-chlorophenyl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-N-(4-chlorophenyl)pyridin-2-amine; N-(4-Chlorophenyl)-4-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; Pinacol ester of [5-Amino-6-(4-chlorophenylamino)-4-methylpyridin-3-yl]boronic acid; CAS 1350643-83-2
EINECS	Contact for details

Quality Control

Our n-(4-Chlorophenyl)-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.