Description

(Z)-3-(6-Fluoro-1H-Indol-3-Yl)Acrylonitrile is a high-value fluorinated indole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in its unique molecular architecture, which combines a fluorinated indole scaffold with an acrylonitrile moiety, enabling precise modifications in complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in oncology and CNS (Central Nervous System) therapeutic areas.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging the bioactivity of the fluorinated indole structure.
• Chemical Biology Probe: Serves as a precursor for fluorescent tags or molecular probes to study biological pathways and protein interactions.
• Material Science Precursor: Potential starting material for advanced organic electronic materials due to its conjugated system.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) settings for methodological development and discovery chemistry.

Basic Information

Product Name	(Z)-3-(6-Fluoro-1H-Indol-3-Yl)Acrylonitrile
CAS No.	1350543-67-7
Molecular Formula	C11H7FN2
Molecular Weight	186.19 g/mol
Synonyms	(Z)-3-(6-Fluoro-1H-indol-3-yl)acrylonitrile; (Z)-3-(6-Fluoro-1H-indol-3-yl)-2-propenenitrile; 6-Fluoro-3-[(Z)-2-cyanoethenyl]-1H-indole; (Z)-3-(6-Fluoroindol-3-yl)acrylonitrile; 3-[(1Z)-2-Cyanoethenyl]-6-fluoro-1H-indole; (Z)-3-(6-Fluoro-1H-indol-3-yl)prop-2-enenitrile; 6-Fluoro-3-[(1Z)-2-cyanoethenyl]-1H-indole
EINECS	Contact for details

Quality Control

Our (Z)-3-(6-Fluoro-1H-Indol-3-Yl)Acrylonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material produced under cGMP (current Good Manufacturing Practice) guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere if prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.