Description

Racemic-(3As,8R,8As)-tert-Butyl 8-Hydroxy-3,3A,8,8A-Tetrahydroindeno[1,2-C]Pyrrole-2(1H)-Carboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, offering a rigid, fused polycyclic structure that is valuable in medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel therapeutic agents.
• Medicinal Chemistry: Used as a scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Acts as a precursor or template in the synthesis of enantiomerically pure compounds for pharmacological evaluation.
• Process Chemistry: Employed in the scale-up and route development for the commercial manufacturing of candidate drugs.
• Chemical Biology: Utilized in the design and synthesis of molecular probes to study biological pathways and target engagement.
• Academic Research: A valuable reagent for methodological development in organic synthesis and catalysis studies at universities and research institutes.

Basic Information

Product Name	Racemic-(3As,8R,8As)-tert-Butyl 8-Hydroxy-3,3A,8,8A-Tetrahydroindeno[1,2-C]Pyrrole-2(1H)-Carboxylate
CAS No.	1350475-48-7
Molecular Formula	C16H21NO3
Molecular Weight	275.34 g/mol
Synonyms	tert-Butyl 8-hydroxy-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole-2-carboxylate; (3aRS,8RS,8aRS)-tert-Butyl 8-hydroxy-3,3a,8,8a-tetrahydro-1H-indeno[1,2-c]pyrrole-2(3H)-carboxylate; 1H-Indeno[1,2-c]pyrrole-2(3H)-carboxylic acid, 3,3a,8,8a-tetrahydro-8-hydroxy-, 1,1-dimethylethyl ester, (3aR*,8R*,8aR*)-; 1350475-48-7; rac-(3aR,8R,8aR)-tert-Butyl 8-hydroxy-3,3a,8,8a-tetrahydroindeno[1,2-c]pyrrole-2(1H)-carboxylate; Indenopyrrolidine carboxylate derivative; Chiral indenopyrrolidine building block
EINECS	Contact for details

Quality Control

Our Racemic-(3As,8R,8As)-tert-Butyl 8-Hydroxy-3,3A,8,8A-Tetrahydroindeno[1,2-C]Pyrrole-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	Racemic mixture
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.