Description

5-Bromo-2-Chloro-4-Fluorobenzenethiol is a high-purity, multi-halogenated benzenethiol derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring bromo, chloro, and fluoro substituents alongside a reactive thiol group, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as drug discovery, ligand synthesis, and the development of novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the halogen pattern for enhanced bioactivity and environmental stability.
• Ligand and Catalyst Development: Used to create sophisticated ligands for transition metal catalysis, enabling challenging cross-coupling and C-H activation reactions.
• Material Science Research: Intermediate in the development of organic electronic materials, such as charge-transport layers and semiconductors.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated thiophenol motifs.
• Life Sciences Research: Utilized in biochemical research for protein modification and as a precursor for fluorescent probes and other diagnostic tools.

Basic Information

Product Name	5-Bromo-2-Chloro-4-Fluorobenzenethiol
CAS No.	1349718-67-7
Molecular Formula	C6H3BrClFS
Molecular Weight	241.51 g/mol
Synonyms	2-Chloro-4-fluoro-5-bromobenzenethiol; 4-Fluoro-5-bromo-2-chlorobenzenethiol; 5-Bromo-2-chloro-4-fluorothiophenol; 1-Bromo-4-chloro-2-fluoro-6-mercaptobenzene; Benzenethiol, 5-bromo-2-chloro-4-fluoro-; (5-Bromo-2-chloro-4-fluorophenyl)thiol
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Chloro-4-Fluorobenzenethiol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment. Our quality commitment ensures batch-to-batch consistency and traceability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.