Description

tert-Butyl 3-Hydroxy-1-Oxa-6-Azaspiro[3.3]Heptane-6-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and metabolic disorders. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in innovative drug discovery programs.

Application

• Key Intermediate in Drug Discovery: Serves as a crucial building block for synthesizing complex molecules with potential therapeutic activity.
• Spirocyclic Scaffold Construction: Used to incorporate the 1-oxa-6-azaspiro[3.3]heptane moiety, a privileged structure in medicinal chemistry known to improve drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Utilized in the synthesis of linkers and warhead components for targeted protein degradation therapeutics.
• CNS-Active Compound Synthesis: Applied in the research and development of potential treatments for neurological and psychiatric conditions.
• Peptidomimetic and Bioisostere Research: Acts as a versatile synthon for creating peptide mimics and bioisosteric replacements in lead optimization.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of candidate drugs.

Basic Information

Product Name	tert-Butyl 3-Hydroxy-1-Oxa-6-Azaspiro[3.3]Heptane-6-Carboxylate
CAS No.	1349199-63-8
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	6-Boc-3-hydroxy-1-oxa-6-azaspiro[3.3]heptane; 3-Hydroxy-1-oxa-6-azaspiro[3.3]heptane-6-carboxylic acid tert-butyl ester; tert-Butyl 3-hydroxy-1-oxa-6-azaspiro[3.3]heptane-6-carboxylate; 1-Oxa-6-azaspiro[3.3]heptane-6-carboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester; Boc-Protected 3-Hydroxy-1-oxa-6-azaspiro[3.3]heptane; 3-Hydroxy-6-((tert-butoxycarbonyl)amino)-1-oxa-6-azaspiro[3.3]heptane
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Hydroxy-1-Oxa-6-Azaspiro[3.3]Heptane-6-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.