Description

Thiol-Peg3-Acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal thiol and a carboxylic acid group, separated by a triethylene glycol spacer. This compound is essential for creating stable, hydrophilic, and biocompatible conjugates in advanced bioconjugation and materials science. It is a critical reagent for researchers and manufacturers in pharmaceutical development, proteomics, and nanotechnology, enabling the precise modification of peptides, proteins, and surfaces.

Application

• Bioconjugation and Crosslinking: Used to covalently link biomolecules (e.g., antibodies, peptides) to surfaces, nanoparticles, or other proteins via thiol and carboxylate chemistry.
• PEGylation Reagent: Serves as a heterobifunctional linker for creating PEGylated drug conjugates to improve solubility, stability, and pharmacokinetics.
• Surface Functionalization: Enables the modification of gold nanoparticles, biosensors, and microarray slides with thiol-gold self-assembled monolayers (SAMs) terminated with a carboxylic acid for further coupling.
• Hydrogel Synthesis: Acts as a building block in the formation of hydrogels for tissue engineering and drug delivery systems.
• ADC (Antibody-Drug Conjugate) Development: Facilitates the site-specific attachment of cytotoxic payloads to antibodies.
• Diagnostic Reagent Preparation: Used in the development of diagnostic assays and imaging probes.

Basic Information

Product Name	Thiol-Peg3-Acid
CAS No.	1347750-82-6
Molecular Formula	C11H22O6S
Molecular Weight	282.35 g/mol
Synonyms	3,6,9-Trioxa-12-mercaptododecanoic acid; 11-Mercapto-3,6,9-trioxaundecanoic acid; HS-PEG3-COOH; Thiol-PEG3-propionic acid; SH-PEG3-COOH; 2-[2-[2-(2-Mercaptoethoxy)ethoxy]ethoxy]acetic acid; α-Thio-ω-carboxy-triethylene glycol; PEG3 thiol acid linker
EINECS	Contact for details

Quality Control

Our Thiol-Peg3-Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay is provided with every shipment. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Titration)	≥ 90%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.