Description

Propargyl-Peg4-Thiol CAS NO 1347750-80-4 is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal thiol group for conjugation and a terminal propargyl group for click chemistry reactions. This compound is essential for creating stable, site-specific bioconjugates and functionalized materials with controlled spacing and solubility. It is primarily needed by researchers and manufacturers in bioconjugation, pharmaceutical development, nanotechnology, and surface functionalization for applications ranging from drug delivery systems to biosensors.

Application

• Bioconjugation and Protein/Peptide Labeling: Used to attach fluorescent dyes, drugs, or other molecules to biomolecules via thiol-maleimide or thiol-haloacetyl chemistry, with the propargyl group available for subsequent click chemistry modifications.
• Drug Delivery System Development: Serves as a key building block for constructing PEGylated drug conjugates, antibody-drug conjugates (ADCs), and liposomal formulations to enhance solubility, stability, and pharmacokinetics.
• Surface Functionalization and Material Science: Enables the modification of nanoparticles, gold surfaces, quantum dots, and hydrogels to introduce bio-recognition elements or alter surface properties.
• Click Chemistry Scaffold: The propargyl group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC), allowing for efficient, modular assembly of complex molecular architectures.
• Crosslinking Agent: Can be used to crosslink polymers or biomaterials through dual-reactive thiol and alkyne functionalities, creating tailored networks for tissue engineering or controlled release.
• Diagnostic Reagent Synthesis: Employed in the fabrication of diagnostic probes and assay components where specific, stable attachment of recognition elements is required.

Basic Information

Product Name	Propargyl-Peg4-Thiol
CAS No.	1347750-80-4
Molecular Formula	C15H28O5S
Molecular Weight	320.45 g/mol
Synonyms	Propargyl-PEG4-thiol; 2,5,8,11-Tetraoxatetradec-13-yne-14-thiol; 3-((2-(2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)ethoxy)ethyl)thio)propan-1-ol; Propargyl tetraethylene glycol thiol; Propargyl-PEG4-SH; Alkyne-PEG4-thiol; Thiol-PEG4-propargyl; 1-Thio-ω-propargyl tetraethylene glycol
EINECS	Contact for details

Quality Control

Our Propargyl-Peg4-Thiol is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FT-IR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. We adhere to relevant industry standards to support your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This product is easily oxidized and moisture-sensitive; ensure containers are sealed tightly after each use to minimize exposure to air and humidity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in water, DMSO, DMF, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.