Description

Nefopam-D3 Hydrochloride CAS NO 1346747-15-6 is a deuterated analog of the centrally-acting analgesic, Nefopam Hydrochloride, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard for precise quantitative analysis in bioanalytical and pharmacokinetic studies. It is primarily required by pharmaceutical research and development laboratories, clinical testing facilities, and contract research organizations (CROs) engaged in drug metabolism and pharmacodynamics (DMPK) research.

Application

• Primary use as a stable isotope-labeled internal standard for the accurate quantification of Nefopam in biological matrices (e.g., plasma, serum, urine) using LC-MS/MS and GC-MS methods.
• Critical component in pharmacokinetic (PK) and bioequivalence studies for generic and novel formulations of Nefopam.
• Essential reference material for drug metabolism research, aiding in the identification and characterization of metabolites.
• Used in the development and validation of regulatory-compliant analytical methods for clinical and non-clinical trials.
• Supports forensic and toxicology laboratories in the precise analysis of Nefopam for medico-legal purposes.
• Facilitates high-quality research in analytical chemistry and pharmaceutical sciences within academic and industrial settings.

Basic Information

Product Name	Nefopam-D3 Hydrochloride
CAS No.	1346747-15-6
Molecular Formula	C17H16D3NO•HCl
Molecular Weight	295.82 g/mol (approx.)
Synonyms	5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine-D3 Hydrochloride; Fenazoxine-D3 Hydrochloride; Acupan-D3 Hydrochloride; Nefopam-d3 HCl; [2H3]-Nefopam Hydrochloride; 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine-D3 Hydrochloride; Benzoxazocine-D3 Derivative
EINECS	Contact for details

Quality Control

Our Nefopam-D3 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.