Description

Esmolol-D7 Hcl CAS NO 1346746-38-0 is a deuterium-labeled analog of the ultra-short-acting cardioselective β-1 adrenergic receptor blocker, Esmolol Hydrochloride. This stable isotope-labeled compound is an essential internal standard for the precise quantification of Esmolol in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development and validation.

Application

• Bioanalytical Internal Standard: Serves as a critical reference compound for the accurate and reliable quantification of Esmolol in plasma, serum, and other biological samples via mass spectrometry.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• LC-MS/MS Method Development: Used as a deuterated internal standard to improve assay accuracy, precision, and to correct for matrix effects and instrument variability.
• Doping Control & Forensic Analysis: Supports the detection and confirmation of Esmolol in forensic toxicology and sports anti-doping programs.
• Pharmaceutical Quality Control: Can be utilized in advanced impurity profiling and stability-indicating assay methods for Esmolol drug products.
• Isotope Dilution Mass Spectrometry (IDMS): Fundamental for achieving high metrological accuracy in quantitative analyses requiring the highest level of certainty.

Basic Information

Product Name	Esmolol-D7 Hcl
CAS No.	1346746-38-0
Molecular Formula	C16H18D7NO4 • HCl
Molecular Weight	337.85 g/mol (approx.)
Synonyms	Esmolol-d7 Hydrochloride; Methyl 3-[4-[2-Hydroxy-3-(isopropylamino)propoxy]phenyl]propionate-d7 Hydrochloride; ASL-8052-d7; Brevibloc-d7; (RS)-Esmolol-d7 HCl; 4'-[2-Hydroxy-3-(isopropylamino)propoxy]methyl hydrocinnamate-d7 hydrochloride
EINECS	Contact for details

Quality Control

Our Esmolol-D7 Hcl is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including NMR (¹H, ²H) for isotopic enrichment verification and HPLC for chemical and isotopic purity assessment. We provide comprehensive Certificates of Analysis (COA) detailing batch-specific results for purity, isotopic abundance, and identity. Our quality commitment ensures the material meets the exacting standards required for sensitive bioanalytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (²H NMR)	≥ 98.0 atom % D
Chemical Purity (¹H NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.