Description

1H-Indazole-4-Carboxamide,6-Bromo-1-Cyclopentyl-n-[(1,2-Dihydro-4,6-Dimethyl-2-Oxo-3-Pyridinyl)Methyl]- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value for its role as a key building block in the research and development of novel therapeutic agents, particularly in oncology and targeted drug discovery. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of potent and selective small-molecule inhibitors.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Development: Serves as a core scaffold for designing and optimizing potent kinase inhibitors targeting specific cancer pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical entities with improved efficacy and pharmacokinetic profiles.
• Biochemical Probe Synthesis: Employed to create tool compounds for studying enzyme function and cellular signaling mechanisms in biological research.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	1H-Indazole-4-Carboxamide,6-Bromo-1-Cyclopentyl-n-[(1,2-Dihydro-4,6-Dimethyl-2-Oxo-3-Pyridinyl)Methyl]-
CAS No.	1346703-22-7
Molecular Formula	C21H25BrN4O2
Molecular Weight	445.36 g/mol
Synonyms	6-Bromo-1-cyclopentyl-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1H-indazole-4-carboxamide; 6-Bromo-1-cyclopentyl-1H-indazole-4-carboxylic acid (1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinylmethyl)amide; UNII-8W2J3K3F9R; 8W2J3K3F9R; 1346703-22-7; 6-Bromo-1-cyclopentyl-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-1H-indazole-4-carboxamide
EINECS	Contact for details

Quality Control

Our 1H-Indazole-4-Carboxamide,6-Bromo-1-Cyclopentyl-n-[(1,2-Dihydro-4,6-Dimethyl-2-Oxo-3-Pyridinyl)Methyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed chromatographic data are available upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.