Description

(2R)-1-(1,1,1,2,3,3,3-Heptadeuteriopropan-2-Ylamino)-3-Naphthalen-1-Yloxypropan-2-Ol Hydrochloride is a deuterated derivative of propranolol hydrochloride, a well-known non-selective β-adrenergic receptor blocker. This compound is specifically designed for use as an internal standard in analytical chemistry, offering superior precision for quantitative analysis in complex matrices. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Essential for accurate quantification of propranolol and related compounds in biological samples (plasma, serum, urine) due to its nearly identical chemical properties with distinct mass.
• Pharmaceutical Research & Development: Used in method development and validation for drug metabolism and pharmacokinetics (DMPK) studies.
• Bioanalytical Assays: Critical component in high-precision assays to determine drug concentration, ensuring reliability and meeting regulatory standards for data integrity.
• Metabolite Tracing: Aids in the identification and quantification of drug metabolites in preclinical and clinical studies.
• Quality Control in Manufacturing: Serves as a reference standard for the quality control of propranolol hydrochloride active pharmaceutical ingredient (API) and finished dosage forms.
• Forensic and Clinical Toxicology: Employed in confirmatory testing for propranolol and in research on its physiological effects.

Basic Information

Product Name	(2R)-1-(1,1,1,2,3,3,3-Heptadeuteriopropan-2-Ylamino)-3-Naphthalen-1-Yloxypropan-2-Ol Hydrochloride
CAS No.	1346617-25-1
Molecular Formula	C₁₆H₁₇D₇ClNO₂
Molecular Weight	309.88 g/mol (for monoisotopic mass)
Synonyms	Deuterated Propranolol-d7 Hydrochloride; (R)-Propranolol-d7 HCl; 1-((1-Methylethyl-d7)amino)-3-(1-naphthalenyloxy)-2-propanol Hydrochloride; (2R)-1-[(2S)-1,1,1,2,3,3,3-Heptadeuterio-2-propanyl]amino]-3-(1-naphthalenyloxy)-2-propanol Hydrochloride; (R)-1-(Isopropylamino-d7)-3-(naphthalen-1-yloxy)propan-2-ol Hydrochloride; Propranolol-d7 (Hydrochloride); Internal Standard for Propranolol Quantification.
EINECS	Contact for details

Quality Control

Every batch of our deuterated analytical standards is produced and tested under strict quality management systems. We guarantee high chemical and isotopic purity as verified by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for identity, purity (HPLC assay), isotopic enrichment, and other critical parameters to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Keep the container tightly sealed in a dry place after each use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (Mass)	Conforms to structure (M+H+)
Purity (HPLC)	≥ 98.0%
Isotopic Purity (d7)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.