Description

(S)-Desfluoro Citalopram-D6 Oxalate is a high-purity, isotopically labeled reference standard of the selective serotonin reuptake inhibitor (SSRI) citalopram. This compound is specifically designed for use in quantitative analytical methods, providing unmatched accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities engaged in bioanalytical method development, drug metabolism and pharmacokinetics (DMPK) research, and clinical trial sample analysis.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical, stable isotope-labeled internal standard for the precise quantification of citalopram and its metabolites in complex biological matrices like plasma, serum, and urine.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate highly sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for therapeutic drug monitoring (TDM) and pharmacokinetic studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Forensic and Clinical Toxicology: Employed in confirmatory testing for citalopram presence and concentration in forensic investigations and clinical overdose cases, ensuring legally defensible results.
• Pharmaceutical Quality Control: Acts as a reference material for impurity profiling and stability testing of citalopram drug substances and finished pharmaceutical products.

Basic Information

Product Name	(S)-Desfluoro Citalopram-D6 Oxalate
CAS No.	1346617-15-9
Molecular Formula	C21H19D6FN2O•C2H2O4
Molecular Weight	446.53 g/mol
Synonyms	(S)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-(trideuteriomethyl)isobenzofuran-D3 oxalate; (S)-Desfluoro Citalopram D6 Oxalate Salt; Deuterated Citalopram Oxalate; Citalopram-d6 (S-enantiomer) Oxalate; 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-(trideuteriomethyl)isobenzofuran-D3, (3S)-, oxalate; Escitalopram Related Compound D6 Oxalate
EINECS	Contact for details

Quality Control

Every batch of (S)-Desfluoro Citalopram-D6 Oxalate is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Our products are supplied with a detailed Certificate of Analysis (COA) that includes data for isotopic purity (D-enrichment), chemical purity (HPLC), and structural confirmation. We ensure compliance with the high standards required for reference materials in regulated bioanalysis.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98.0 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.