Description

(R)-2-Methylbutyric Acid-D3 is a chiral, deuterium-labeled carboxylic acid used as a high-value isotopic tracer in pharmaceutical and metabolic research. Its deuterated structure (D3 at the methyl group) ensures enhanced metabolic stability and precise tracking in in vivo and in vitro studies, enabling accurate pharmacokinetic and mechanistic profiling. This compound is essential for researchers developing chiral APIs, conducting isotope effect studies, or synthesizing labeled reference standards — particularly in contract research organizations (CROs), API manufacturers, and academic medicinal chemistry labs. The product is supplied under strict quality controls to meet the demanding requirements of regulatory-compliant analytical and synthetic workflows.

Application

• Chiral drug metabolism studies: Used as an internal standard or tracer to quantify enantioselective biotransformation of 2-methylbutyric acid derivatives
• Synthesis of deuterated active pharmaceutical ingredients (APIs): Key building block for preparing isotopically enriched candidates with improved ADME profiles
• NMR spectroscopy reference standard: Provides sharp, non-exchangeable deuterium signals for structural confirmation and quantitative analysis
• Stable isotope labeling in mass spectrometry (MS): Enables multiplexed quantitation in LC-MS/MS bioanalysis of short-chain fatty acid pathways
• Enzyme mechanism investigation: Probes stereospecificity of acyl-CoA synthetases, dehydrogenases, and β-oxidation enzymes
• Development of certified reference materials (CRMs): Serves as primary calibrant for regulatory-grade assays under ISO 17034

Basic Information

Product Name	(R)-2-Methylbutyric Acid-D3
CAS No.	1346617-08-0
Molecular Formula	C5H7D3O2
Molecular Weight	105.13 g/mol
Synonyms	(R)-2-Methylbutanoic acid-d3; (R)-2-Methylbutyric acid-3,3,3-d3; (R)-(+)-2-Methylbutyric acid-d3; (R)-2-Methylbutanoic acid-3,3,3-d3; (R)-2-Methylbutanoic-d3 acid; D-2-Methylbutyric acid-d3; (R)-α-Methylbutyric acid-d3; (R)-2-Methylbutanoic acid (deuterated, 99% D)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for chiral purity (≥99% ee by chiral HPLC), isotopic enrichment (≥98% D at C-3 position), and chemical purity (≥98.5% by GC and HPLC). Testing follows validated methods aligned with ICH Q2(R2) guidelines, and manufacturing adheres to ISO 9001-certified quality management systems. Regulatory support documentation (including REACH registration status and FDA Drug Master File (DMF) readiness) is available for qualified customers.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25 °C in a dry, well-ventilated area. Avoid exposure to moisture and strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Odor	Characteristic pungent, rancid odor
Optical Rotation ([α]D20)	+12.5° to +13.5° (c = 1 in CHCl3)
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (by GC)	≥98.5%
Chiral Purity (by Chiral HPLC)	≥99% ee
Isotopic Enrichment (by 2H NMR)	≥98% D at C-3 methyl group
Residue on Ignition	≤0.1%
Water (KF)	≤0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.