Description

L-2-Aminobutyric Acid-D5 Methyl Ester Hydrochloride is a stable isotope-labeled derivative of the amino acid 2-aminobutyric acid, where five hydrogen atoms are replaced by deuterium. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research and development laboratories, clinical diagnostic facilities, and academic institutions engaged in metabolomics, pharmacokinetic studies, and biomarker discovery.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the precise quantification of endogenous 2-aminobutyric acid and related metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) of drug candidates.
• Clinical Diagnostics & Metabolomics: Enables accurate profiling of metabolic pathways for disease research, including studies related to liver function, inborn errors of metabolism, and nutritional status.
• Stable Isotope Labeling: Acts as a building block or tracer in the synthesis of more complex deuterated compounds for advanced research applications.
• Quality Control & Method Validation: Essential for developing, validating, and ensuring the compliance of analytical methods in regulated environments (GLP, GCP).

Basic Information

Product Name	L-2-Aminobutyric Acid-D5 Methyl Ester Hydrochloride
CAS No.	1346617-05-7
Molecular Formula	C5H5D5ClNO2
Molecular Weight	168.64 g/mol
Synonyms	(2S)-2-Amino-D5-butyric Acid Methyl Ester Hydrochloride; L-2-Amino-D5-butyric Acid Methyl Ester HCl; Methyl L-2-Amino-D5-butyrate Hydrochloride; (S)-2-Amino-D5-butyric Acid Methyl Ester Hydrochloride; Deuterated 2-AB Methyl Ester HCl; 2-AB-D5 Methyl Ester Hydrochloride; Internal Standard for 2-Aminobutyric Acid
EINECS	Contact for details

Quality Control

Our L-2-Aminobutyric Acid-D5 Methyl Ester Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic enrichment (by MS), and chiral purity. We adhere to industry best practices to support research in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D5)	≥ 98 atom % D
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.