Description

4,4-Dimethyl Retinoic Acid-D3 CAS NO 1346606-19-6 is a stable isotope-labeled analog of retinoic acid, specifically deuterated at the 4,4-dimethyl positions. This compound is critical for high-precision analytical and metabolic studies, serving as an essential internal standard for accurate quantification via mass spectrometry. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in retinoid pathway research, drug metabolism and pharmacokinetics (DMPK), and biomarker analysis.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of retinoic acid and its metabolites in biological matrices.
• Drug Metabolism Studies (DMPK): Facilitates tracing and understanding the metabolic fate of retinoid-based pharmaceuticals in preclinical and clinical research.
• Biomarker Research: Enables accurate measurement of endogenous retinoic acid levels in studies related to dermatology, oncology, and developmental biology.
• Stable Isotope Labeling: Serves as a key reagent in the synthesis of more complex labeled compounds for advanced metabolic tracing experiments.
• Quality Control & Method Development: Essential for developing and validating robust bioanalytical methods in compliance with GLP and FDA guidelines.
• Academic Research: Supports fundamental research into vitamin A signaling, cell differentiation, and proliferation mechanisms.

Basic Information

Product Name	4,4-Dimethyl Retinoic Acid-D3
CAS No.	1346606-19-6
Molecular Formula	C22H29D3O2
Molecular Weight	331.5 g/mol (approx.)
Synonyms	4,4-Dimethyl-13,14,19,20-tetradehydroretinoic Acid-d3; (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic-19,19,20,20-d4 Acid; Deuterated 4,4-Dimethyl Retinoic Acid; 4,4-DMRA-d3; Isotopically Labeled Retinoic Acid; Retinoid Internal Standard; 4,4-Dimethyl Tretinoin-d3
EINECS	Contact for details

Quality Control

Our 4,4-Dimethyl Retinoic Acid-D3 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity by HPLC, and confirmation of structure. We adhere to standards relevant for high-purity reference materials and can provide support for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.