Description

2-[[1,1,1,3,3,3-Hexadeuterio-2-(Trideuteriomethyl)Propan-2-Yl]Amino]-1-[4-Hydroxy-3-(Hydroxymethyl)Phenyl]Ethanone:Hydrochloride CAS NO 1346605-08-0 is a deuterated derivative of a key pharmaceutical intermediate, offering enhanced metabolic stability and traceability for advanced research and development. This high-purity compound is critical for applications requiring precise isotopic labeling, such as in pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development of novel therapeutics.

Application

• Isotopic Labeling in Drug Metabolism and Pharmacokinetics (DMPK) Studies: Serves as an internal standard or tracer for quantitative mass spectrometry analysis.
• Pharmaceutical Intermediate: Used in the synthesis of deuterated drug candidates to improve metabolic profiles and patent life.
• Biomedical Research: Employed in mechanistic studies to elucidate metabolic pathways and enzyme activities.
• Analytical Reference Standard: Provides a certified material for method development and validation in bioanalytical laboratories.
• Preclinical Development: Facilitates accurate tracking of compound distribution and clearance in animal models.

Basic Information

Product Name	2-[[1,1,1,3,3,3-Hexadeuterio-2-(Trideuteriomethyl)Propan-2-Yl]Amino]-1-[4-Hydroxy-3-(Hydroxymethyl)Phenyl]Ethanone:Hydrochloride
CAS No.	1346605-08-0
Molecular Formula	C14H15D9ClNO3
Molecular Weight	304.83 g/mol (for monoisotopic mass)
Synonyms	Deuterated Adrenalone tert-Butylamine Hydrochloride; 1-(4-Hydroxy-3-(hydroxymethyl)phenyl)-2-((1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propan-2-yl)amino)ethan-1-one hydrochloride; Adrenalone-d9 (tert-butylamine) HCl; [D9]-Adrenalone tert-Butylamine Hydrochloride; 3',4'-Dihydroxy-2-((2-methyl-1,1,1,3,3,3-d6-propan-2-yl-d3)amino)acetophenone Hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm isotopic enrichment, chemical purity, and identity. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to cGMP principles where applicable to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (¹H, ¹³C, ²H)
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.