Description

3-[(2-Methylimidazol-1-Yl)Methyl]-9-(Trideuteriomethyl)-2,3-Dihydro-1H-Carbazol-4-One:Hydrochloride is a high-purity, deuterated chemical intermediate of significant interest in advanced pharmaceutical research and development. Its core value lies in its role as a key building block for creating novel, isotopically labeled compounds, which are essential for drug metabolism and pharmacokinetic (DMPK) studies. This product is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who are developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of deuterated drug candidates for improved metabolic stability and prolonged half-life.
• Metabolic Tracer Development: Used to create isotopically labeled internal standards for accurate Liquid Chromatography-Mass Spectrometry (LC-MS) bioanalysis in clinical and pre-clinical trials.
• Mechanism of Action (MOA) Studies: Enables the tracing of biochemical pathways and the identification of metabolites, providing deeper insights into a drug's behavior in biological systems.
• Proteomics and Biomarker Research: Facilitates the development of chemical probes and affinity tags for studying protein interactions and disease mechanisms.
• Academic and Institutional Research: Supports fundamental chemical and biological research in universities and government labs focusing on heterocyclic and carbazole chemistry.

Basic Information

Product Name	3-[(2-Methylimidazol-1-Yl)Methyl]-9-(Trideuteriomethyl)-2,3-Dihydro-1H-Carbazol-4-One:Hydrochloride
CAS No.	1346605-02-4
Molecular Formula	C18H17D3ClN3O
Molecular Weight	329.85 g/mol
Synonyms	9-(Trideuteriomethyl)-3-[(2-methyl-1H-imidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one hydrochloride; Deuterated Carbazole-Imidazole Hybrid HCl Salt; 9-(CD3)-3-[(2-Methylimidazol-1-yl)methyl]-2,3-dihydrocarbazol-4-one hydrochloride; 1346605-02-4; Carbazol-4-one, 9-(trideuteriomethyl)-3-[(2-methyl-1H-imidazol-1-yl)methyl]-2,3-dihydro-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Every batch of 3-[(2-Methylimidazol-1-Yl)Methyl]-9-(Trideuteriomethyl)-2,3-Dihydro-1H-Carbazol-4-One:Hydrochloride is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and isotopic enrichment meet the exacting standards required for research and development. A detailed Certificate of Analysis (COA) including results for assay, deuterium incorporation, and impurity profile (by HPLC) is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.