Description

2,2-Dimethyl-1,3-Dioxolane-4-Methanol 4-Methanesulfonate-D5 is a deuterated derivative of a key protected glycerol synthon, specifically designed for advanced research and development. This compound is valued for its role as a stable isotope-labeled intermediate, enabling precise metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical and agrochemical R&D teams, as well as academic researchers, for applications in tracer studies, analytical method development, and the synthesis of labeled active pharmaceutical ingredients (APIs).

Application

• Stable Isotope Labeling: Serves as a crucial deuterium-labeled building block for the synthesis of isotopically labeled compounds in pharmaceutical research.
• Metabolic Pathway Tracing: Used in mass spectrometry-based studies to track and quantify drug metabolites and biochemical pathways.
• Internal Standard Synthesis: A key precursor for creating high-purity deuterated internal standards for quantitative analytical methods like LC-MS and GC-MS.
• Pharmaceutical R&D: Employed in the development and scale-up of novel drug candidates where isotopic labeling is required for regulatory or mechanistic studies.
• Agrochemical Research: Applied in the development of labeled pesticides or herbicides to study environmental fate, degradation, and residue analysis.
• Academic Research: Utilized in chemical biology and organic chemistry laboratories for mechanistic investigations and advanced synthetic methodologies.

Basic Information

Product Name	2,2-Dimethyl-1,3-Dioxolane-4-Methanol 4-Methanesulfonate-D5
CAS No.	1346604-82-7
Molecular Formula	C7H8D5O5S
Molecular Weight	212.25 g/mol (approx.)
Synonyms	Deuterated Acetonide Glycerol Mesylate-D5; (R/S)-2,2-Dimethyl-1,3-dioxolane-4-methanol 4-methanesulfonate-d5; 1,2-O-Isopropylidene-D5-glycerol 3-mesylate; Isopropylidene-D5-glycerol methanesulfonate; Glycerol Acetonide Mesylate-D5; D5-Labelled Solketal Mesylate; 3-O-Mesyl-1,2-O-isopropylidene-D5-glycerol; Deuterated Glycidyl Mesylate Precursor
EINECS	Contact for details

Quality Control

Our 2,2-Dimethyl-1,3-Dioxolane-4-Methanol 4-Methanesulfonate-D5 is produced under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity, isotopic enrichment (D-content), and impurity profile. We adhere to relevant industry standards for fine chemicals and advanced intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.