Description

Esmolol-D7 Acid Sodium Salt is a deuterium-labeled isotopic analog of esmolol acid, specifically incorporating seven deuterium atoms at defined positions to enable precise pharmacokinetic and metabolic tracing in preclinical and clinical research. It serves as a critical internal standard and reference material for quantitative bioanalysis—particularly in LC-MS/MS assays—where high isotopic fidelity and chemical stability are essential for accurate drug metabolism studies. This compound is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory bioanalytical labs engaged in cardiovascular drug development and ADME (Absorption, Distribution, Metabolism, Excretion) profiling.

Application

• Internal standard for LC-MS/MS quantification of esmolol and its metabolites in plasma, urine, and tissue homogenates
• Reference standard in method validation studies for bioequivalence and pharmacokinetic trials
• Tracer compound in mechanistic studies of β-1 adrenergic receptor blocker metabolism
• Calibration material for high-sensitivity mass spectrometry-based biomarker discovery in cardiovascular disease models
• Quality control standard in GMP-compliant bioanalytical laboratories supporting FDA/EMA submissions
• Stable isotope dilution assay (SIDA) component for absolute quantification of esmolol in complex biological matrices
• Tool compound in radiolabel-free isotopic enrichment experiments requiring minimal structural perturbation

Basic Information

Product Name	Esmolol-D7 Acid Sodium Salt
CAS No.	1346604-59-8
Molecular Formula	C16D7H20NO4Na
Molecular Weight	342.36 g/mol (average mass, D7-isotopologue)
Synonyms	(R)-3-{4-[2-Hydroxy-3-(propan-2-yloxy)propoxy]phenyl}propanoic acid sodium salt-d7; Esmolol-d7 sodium; Sodium (R)-3-[4-[2-hydroxy-3-(isopropoxy)propoxy]phenyl]propanoate-d7; Sodium esmolol-d7; (R)-3-[4-(2-Hydroxy-3-isopropoxypropoxy)phenyl]propionic acid sodium salt-d7; Esmolol-2,3,3,4,4,5,5-d7 sodium salt; NSC 748771-d7 sodium salt; Sodium (2R)-3-[4-[2-hydroxy-3-(propan-2-yloxy)propoxy]phenyl]propanoate-d7
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for isotopic enrichment (>98% D-incorporation at designated positions), chemical purity (≥98.5% by HPLC), identity (NMR, IR, MS), residual solvents (ICH Q3C compliant), and heavy metal content (<10 ppm). Testing adheres to USP & EP guidelines for reference standards and follows ISO/IEC 17025 accredited laboratory practices.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, maintain low humidity conditions (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to reference spectrum (¹H, ¹³C, ²H)
Assay (HPLC)	≥98.5%
Isotopic Purity (MS)	≥98% D7 incorporation
Residual Solvents (GC)	Meets ICH Q3C limits
Water Content (Karl Fischer)	≤0.5%
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.